CRISPR-Cas9 editing minimize hearing loss

David Liu a professor at Harvard University led a work where using CRISPR-Cas9 they alter a faulty gene associated with a form of inherited, progressive hearing loss in the tiny ears of newborn mice. Using the breakthrough technology of CRISPR-Cas9 there were able to edit the gene sequence and replace the mutation with the correct DNA sequence. As a consequence, the mice recover the capability to hear again, reducing the deafness.

In general, genetic mutations are responsible for 50% of all cases of deafness, and in particular, the same mutation they were able to correct in mice, also cause hearing loss in humans. So on, they are expecting the same approach could be use in humans in near future.

The scientific work was recently published in the prestigious journal Nature. You can find the whole scientific manuscript in the next link, although if you are not in a university or research centre subscribe to the journal it will ask you to pay for it.

https://www.nature.com/articles/nature25164

2 thoughts on “CRISPR-Cas9 editing minimize hearing loss”

  1. This is a very good work up but requires to be replicated, elaborated and extended quickly by at least a dozen of teams so that it could be put to use for the deaf human beings who require that urgently.

    • That is totally true Sharwan. However we should be happy because this is, at least, the beginning of a long pathway to understand and cure genetic diseases. Although many other studies and clinical trails need to be done before it is apply in humans as a standard therapy, there is always a first one, and this is the one for deaf.

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