CRISPR-Cas9 has been a revolution in genome editing, from bacteria to humans. However, the efficiency delivering Cas9 and the sgRNA is one of the limiting points in the process. Researchers used plasmid-base delivery systems, nano-vesicles or nano-particles to improve the efficiency delivering the CRISPR systems. In this new article, “Active Intracellular Delivery of a Cas9/sgRNA Complex … Read more
The NIH plans to invest $190M during the next 6 years to fund researchers developing tools and technologies to ensure safety and effectiveness in genome editing in humans, focus on non-reproductive somatic cells. NIH Director Dr. Francis S. Collins declare yesterday that “Genome editing technologies such as CRISPR/Cas9 are revolutionizing biomedical research. The focus of the … Read more
(The picture corresponds to the @CRISPRlab at North Carolina State University where Rodolphe Barrangou works as a Professor). Before the end of 2017 we published the announcement of a new scientific journal exclusively based on CRISPR, The CRISPR Journal which belongs to Mary Ann Liebert, Inc Publishers. This week the first edition online came out: “The … Read more
Cacao is an important food crop used widely around the world by 50 million people. However this wonderful plan that allow to make our sweet dreams possible, like chocolate, suffer a numerous of plant diseases. The Innovative Genomic Institute (IGI) an academic research partnership between UC Berkeley and UC San Francisco aims to develop DNA … Read more
Shoukhrat Mitalipov of Oregon Health and Science University, in Portland, has lead the team that carried out the first attempt to genetically modify human embryos with CRISPR. The aim of this project was to demonstrate that it is possible to safely and efficiently correct defective genes that cause inherited diseases in humans. Indeed, this is gene … Read more
David Liu a professor at Harvard University led a work where using CRISPR-Cas9 they alter a faulty gene associated with a form of inherited, progressive hearing loss in the tiny ears of newborn mice. Using the breakthrough technology of CRISPR-Cas9 there were able to edit the gene sequence and replace the mutation with the correct DNA sequence. … Read more